The vaccine deployment in December 2020 signaled a turning point in the COVID-19 pandemic. By the end of May 2021, 40% of the U.S. population was fully vaccinated. But as vaccination rates lagged over the summer, new surges of COVID-19 came, including Delta in the summer of 2021, and now the Omicron variant, which comprises the majority of cases in the U.S.

Researchers around the world have reported that Omicron is more transmissible than Delta, making breakthrough and repeat infections more likely.

The United States as of Nov. 8 reached over 1 million COVID-19-related deaths and 97.7 million COVID-19 cases, according to Johns Hopkins University. Currently, 68.5% of the population is fully vaccinated, and 8.4% of vaccinated people have received the most recently available bivalent booster doses.

Stacker compiled a list of the counties with highest COVID-19 infection rates in Mississippi using data from the U.S. Department of Health & Human Services and vaccination data from Covid Act Now. Counties are ranked by the highest infection rate per 100,000 residents within the week leading up to Nov. 3, 2022. Cumulative cases per 100,000 served as a tiebreaker.

Keep reading to see whether your county ranks among the highest COVID-19 infection rates in your state.

Calvin Beale // Wikimedia Commons

#50. Simpson County, MS

– New cases per 100k in the past week: 26 (7 new cases, +133% change from previous week)
– Cumulative cases per 100k: 30,745 (8,196 total cases)
— 2.1% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 593 (158 total deaths)
— 35.7% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 46.6% (12,420 fully vaccinated)

NatalieMaynor // Wikimedia Commons

#49. Panola County, MS

– New cases per 100k in the past week: 26 (9 new cases, -36% change from previous week)
– Cumulative cases per 100k: 34,929 (11,943 total cases)
— 11.3% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 518 (177 total deaths)
— 18.5% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 49.2% (16,816 fully vaccinated)

Dudemanfellabra // Wikimedia Commons

#48. Lauderdale County, MS

– New cases per 100k in the past week: 27 (20 new cases, +25% change from previous week)
– Cumulative cases per 100k: 28,390 (21,044 total cases)
— 9.6% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 513 (380 total deaths)
— 17.4% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 52.6% (38,999 fully vaccinated)

Chillin662 // Wikimedia Commons

#47. Yazoo County, MS

– New cases per 100k in the past week: 27 (8 new cases, -33% change from previous week)
– Cumulative cases per 100k: 31,947 (9,485 total cases)
— 1.8% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 384 (114 total deaths)
— 12.1% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 50.8% (15,096 fully vaccinated)

Mark Hilton // Wikimedia Commons

#46. Winston County, MS

– New cases per 100k in the past week: 28 (5 new cases, -44% change from previous week)
– Cumulative cases per 100k: 34,603 (6,213 total cases)
— 10.2% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 579 (104 total deaths)
— 32.5% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 49.3% (8,856 fully vaccinated)

Thomas R Machnitzki (thomas@machnitzki.com) // Wikimedia Commons

#45. Quitman County, MS

– New cases per 100k in the past week: 29 (2 new cases, +100% change from previous week)
– Cumulative cases per 100k: 25,854 (1,756 total cases)
— 17.7% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 486 (33 total deaths)
— 11.2% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 55.4% (3,764 fully vaccinated)

Woodlot // Wikimedia Commons

#44. Harrison County, MS

– New cases per 100k in the past week: 30 (63 new cases, -2% change from previous week)
– Cumulative cases per 100k: 30,217 (62,876 total cases)
— 3.8% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 336 (699 total deaths)
— 23.1% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 57.1% (118,841 fully vaccinated)

Scoutandboo // Wikimedia Commons

#43. Madison County, MS

– New cases per 100k in the past week: 31 (33 new cases, -38% change from previous week)
– Cumulative cases per 100k: 27,797 (29,540 total cases)
— 11.5% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 326 (346 total deaths)
— 25.4% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 65.1% (69,212 fully vaccinated)

Jimmy Emerson from Dalton GA // Wikimedia Commons

#42. Sunflower County, MS

– New cases per 100k in the past week: 32 (8 new cases, +33% change from previous week)
– Cumulative cases per 100k: 25,814 (6,482 total cases)
— 17.8% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 510 (128 total deaths)
— 16.7% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 54.5% (13,679 fully vaccinated)

Courtesy of the Mississippi Department of Archives and History // Wikimedia Commons

#41. Lincoln County, MS

– New cases per 100k in the past week: 32 (11 new cases, +57% change from previous week)
– Cumulative cases per 100k: 29,069 (9,928 total cases)
— 7.4% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 477 (163 total deaths)
— 9.2% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 40.1% (13,693 fully vaccinated)

Michlaovic // Wikimedia

#40. Hinds County, MS

– New cases per 100k in the past week: 33 (77 new cases, -41% change from previous week)
– Cumulative cases per 100k: 27,497 (63,749 total cases)
— 12.4% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 358 (830 total deaths)
— 18.1% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 60.0% (139,210 fully vaccinated)

Woodlot // Wikimedia Commons

#39. Stone County, MS

– New cases per 100k in the past week: 33 (6 new cases, 0% change from previous week)
– Cumulative cases per 100k: 34,877 (6,395 total cases)
— 11.1% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 431 (79 total deaths)
— 1.4% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 47.2% (8,656 fully vaccinated)

Mthunter58 // Wikimedia Commons

#38. Oktibbeha County, MS

– New cases per 100k in the past week: 34 (17 new cases, -39% change from previous week)
– Cumulative cases per 100k: 26,223 (13,003 total cases)
— 16.5% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 341 (169 total deaths)
— 22.0% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 52.4% (25,998 fully vaccinated)

Matthew Nichols // Wikimedia Commons

#37. Grenada County, MS

– New cases per 100k in the past week: 34 (7 new cases, +133% change from previous week)
– Cumulative cases per 100k: 29,675 (6,160 total cases)
— 5.5% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 655 (136 total deaths)
— 49.9% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 54.0% (11,219 fully vaccinated)

CapCase // Wikimedia Commons

#36. Neshoba County, MS

– New cases per 100k in the past week: 34 (10 new cases, +67% change from previous week)
– Cumulative cases per 100k: 41,655 (12,129 total cases)
— 32.7% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 845 (246 total deaths)
— 93.4% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 43.6% (12,695 fully vaccinated)

Thomas R Machnitzki // Wikimedia Commons

#35. Tallahatchie County, MS

– New cases per 100k in the past week: 36 (5 new cases, -71% change from previous week)
– Cumulative cases per 100k: 26,729 (3,691 total cases)
— 14.9% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 463 (64 total deaths)
— 5.9% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 42.5% (5,871 fully vaccinated)

Calvin Beale // Wikimedia Commons

#34. Jefferson Davis County, MS

– New cases per 100k in the past week: 36 (4 new cases, -20% change from previous week)
– Cumulative cases per 100k: 30,572 (3,402 total cases)
— 2.6% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 503 (56 total deaths)
— 15.1% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 46.6% (5,186 fully vaccinated)

Sturmgewehr88 // Wikimedia

#33. Forrest County, MS

– New cases per 100k in the past week: 36 (27 new cases, +35% change from previous week)
– Cumulative cases per 100k: 34,693 (25,984 total cases)
— 10.5% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 426 (319 total deaths)
— 2.5% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 45.3% (33,934 fully vaccinated)

Jerrye & Roy Klotz, MD // Wikimedia Commons

#32. Greene County, MS

– New cases per 100k in the past week: 37 (5 new cases, -17% change from previous week)
– Cumulative cases per 100k: 27,300 (3,709 total cases)
— 13.0% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 442 (60 total deaths)
— 1.1% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 38.0% (5,156 fully vaccinated)

Magnolia677 // Wikimedia Commons

#31. Marshall County, MS

– New cases per 100k in the past week: 40 (14 new cases, -44% change from previous week)
– Cumulative cases per 100k: 31,991 (11,291 total cases)
— 1.9% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 513 (181 total deaths)
— 17.4% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 56.8% (20,059 fully vaccinated)

Cohee // Wikimedia Commons

#30. Chickasaw County, MS

– New cases per 100k in the past week: 41 (7 new cases, -36% change from previous week)
– Cumulative cases per 100k: 38,677 (6,615 total cases)
— 23.2% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 579 (99 total deaths)
— 32.5% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 49.7% (8,492 fully vaccinated)

NatalieMaynor // Wikimedia Commons

#29. Rankin County, MS

– New cases per 100k in the past week: 43 (67 new cases, -19% change from previous week)
– Cumulative cases per 100k: 28,373 (44,055 total cases)
— 9.6% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 332 (516 total deaths)
— 24.0% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 52.5% (81,459 fully vaccinated)

Tony Webster // Wikimedia Commons

#28. Attala County, MS

– New cases per 100k in the past week: 44 (8 new cases, -47% change from previous week)
– Cumulative cases per 100k: 35,204 (6,398 total cases)
— 12.1% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 660 (120 total deaths)
— 51.0% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 55.9% (10,155 fully vaccinated)

Natalie Maynor // Wikimedia Commons

#27. Sharkey County, MS

– New cases per 100k in the past week: 46 (2 new cases, +100% change from previous week)
– Cumulative cases per 100k: 25,388 (1,097 total cases)
— 19.1% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 625 (27 total deaths)
— 43.0% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 57.4% (2,481 fully vaccinated)

Cohee // Wikimedia Commons

#26. Benton County, MS

– New cases per 100k in the past week: 48 (4 new cases, 0% change from previous week)
– Cumulative cases per 100k: 32,135 (2,654 total cases)
— 2.4% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 618 (51 total deaths)
— 41.4% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 53.6% (4,424 fully vaccinated)

Marduk // Wikimedia Commons

#25. Leake County, MS

– New cases per 100k in the past week: 48 (11 new cases, -39% change from previous week)
– Cumulative cases per 100k: 32,213 (7,340 total cases)
— 2.6% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 549 (125 total deaths)
— 25.6% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 50.4% (11,490 fully vaccinated)

The diva777 // Wikimedia Commons

#24. Lamar County, MS

– New cases per 100k in the past week: 51 (32 new cases, +100% change from previous week)
– Cumulative cases per 100k: 32,684 (20,703 total cases)
— 4.1% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 265 (168 total deaths)
— 39.4% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 61.0% (38,645 fully vaccinated)

Cohee // Wikimedia Commons

#23. Union County, MS

– New cases per 100k in the past week: 52 (15 new cases, -42% change from previous week)
– Cumulative cases per 100k: 38,039 (10,961 total cases)
— 21.2% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 444 (128 total deaths)
— 1.6% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 40.2% (11,595 fully vaccinated)

Librarylady2726 // Wikimedia Commons

#22. Jones County, MS

– New cases per 100k in the past week: 53 (36 new cases, +57% change from previous week)
– Cumulative cases per 100k: 36,633 (24,946 total cases)
— 16.7% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 455 (310 total deaths)
— 4.1% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 44.6% (30,398 fully vaccinated)

Michaelswikiusername // Wikimedia Commons

#21. Pontotoc County, MS

– New cases per 100k in the past week: 53 (17 new cases, -48% change from previous week)
– Cumulative cases per 100k: 37,403 (12,034 total cases)
— 19.1% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 479 (154 total deaths)
— 9.6% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 42.6% (13,708 fully vaccinated)

Chris Crookston // Wikimedia Commons

#20. Coahoma County, MS

– New cases per 100k in the past week: 54 (12 new cases, +50% change from previous week)
– Cumulative cases per 100k: 34,487 (7,630 total cases)
— 9.8% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 601 (133 total deaths)
— 37.5% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 53.5% (11,836 fully vaccinated)

Cohee // Wikimedia Commons

#19. Calhoun County, MS

– New cases per 100k in the past week: 56 (8 new cases, -27% change from previous week)
– Cumulative cases per 100k: 37,268 (5,352 total cases)
— 18.7% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 536 (77 total deaths)
— 22.7% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 45.7% (6,565 fully vaccinated)

Brewri92535 // Wikimedia Commons

#18. Newton County, MS

– New cases per 100k in the past week: 57 (12 new cases, +50% change from previous week)
– Cumulative cases per 100k: 32,296 (6,788 total cases)
— 2.9% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 485 (102 total deaths)
— 11.0% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 55.1% (11,582 fully vaccinated)

Gabriel D. May // Wikimedia Commons

#17. Marion County, MS

– New cases per 100k in the past week: 57 (14 new cases, +40% change from previous week)
– Cumulative cases per 100k: 33,386 (8,204 total cases)
— 6.3% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 574 (141 total deaths)
— 31.4% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 47.5% (11,676 fully vaccinated)

Thomas R Machnitzki // Wikimedia Commons

#16. DeSoto County, MS

– New cases per 100k in the past week: 60 (111 new cases, -3% change from previous week)
– Cumulative cases per 100k: 31,389 (58,052 total cases)
— 0.0% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 308 (570 total deaths)
— 29.5% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 57.1% (105,519 fully vaccinated)

Hamhari Brown // Wikimedia Commons

#15. Bolivar County, MS

– New cases per 100k in the past week: 72 (22 new cases, +38% change from previous week)
– Cumulative cases per 100k: 35,138 (10,762 total cases)
— 11.9% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 614 (188 total deaths)
— 40.5% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 60.8% (18,615 fully vaccinated)

NatalieMaynor // Wikimedia Commons

#14. Webster County, MS

– New cases per 100k in the past week: 72 (7 new cases, +133% change from previous week)
– Cumulative cases per 100k: 39,488 (3,826 total cases)
— 25.8% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 753 (73 total deaths)
— 72.3% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 49.2% (4,763 fully vaccinated)

Carlcath // Wikimedia Commons

#13. Clay County, MS

– New cases per 100k in the past week: 78 (15 new cases, +150% change from previous week)
– Cumulative cases per 100k: 30,130 (5,820 total cases)
— 4.0% less cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 528 (102 total deaths)
— 20.8% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 48.3% (9,332 fully vaccinated)

Leigh T. Harrell // Wikimedia Commons

#12. Lowndes County, MS

– New cases per 100k in the past week: 84 (49 new cases, +63% change from previous week)
– Cumulative cases per 100k: 34,426 (20,172 total cases)
— 9.7% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 425 (249 total deaths)
— 2.7% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 52.6% (30,823 fully vaccinated)

Cohee // Wikimedia Commons

#11. Lee County, MS

– New cases per 100k in the past week: 90 (77 new cases, +10% change from previous week)
– Cumulative cases per 100k: 37,243 (31,819 total cases)
— 18.6% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 370 (316 total deaths)
— 15.3% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 44.7% (38,209 fully vaccinated)

Rdstephens // Wikimedia Commons

#10. Noxubee County, MS

– New cases per 100k in the past week: 106 (11 new cases, -15% change from previous week)
– Cumulative cases per 100k: 31,641 (3,296 total cases)
— 0.8% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 470 (49 total deaths)
— 7.6% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 56.6% (5,896 fully vaccinated)

Skye Marthaler // Wikimedia Commons

#9. Alcorn County, MS

– New cases per 100k in the past week: 106 (39 new cases, -2% change from previous week)
– Cumulative cases per 100k: 32,647 (12,064 total cases)
— 4.0% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 441 (163 total deaths)
— 0.9% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 40.4% (14,938 fully vaccinated)

Jerrye & Roy Klotz, MD // Wikimedia Commons

#8. Lafayette County, MS

– New cases per 100k in the past week: 113 (61 new cases, +45% change from previous week)
– Cumulative cases per 100k: 33,109 (17,885 total cases)
— 5.5% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 344 (186 total deaths)
— 21.3% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 56.1% (30,321 fully vaccinated)

Cohee // Wikimedia Commons

#7. Tippah County, MS

– New cases per 100k in the past week: 114 (25 new cases, +32% change from previous week)
– Cumulative cases per 100k: 38,501 (8,476 total cases)
— 22.6% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 518 (114 total deaths)
— 18.5% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 43.0% (9,476 fully vaccinated)

Brian Stansberry // Wikimedia Commons

#6. Monroe County, MS

– New cases per 100k in the past week: 128 (45 new cases, +150% change from previous week)
– Cumulative cases per 100k: 36,236 (12,774 total cases)
— 15.4% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 644 (227 total deaths)
— 47.4% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 51.8% (18,250 fully vaccinated)

Nlsanfor // Wikimedia Commons

#5. Covington County, MS

– New cases per 100k in the past week: 129 (24 new cases, +243% change from previous week)
– Cumulative cases per 100k: 43,840 (8,170 total cases)
— 39.6% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 633 (118 total deaths)
— 44.9% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 57.9% (10,793 fully vaccinated)

Fredlyfish4 // Wikimedia Commons

#4. Itawamba County, MS

– New cases per 100k in the past week: 133 (31 new cases, +107% change from previous week)
– Cumulative cases per 100k: 37,785 (8,838 total cases)
— 20.3% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 628 (147 total deaths)
— 43.7% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 35.6% (8,326 fully vaccinated)

Skye Marthaler // Wikimedia Commons

#3. Tishomingo County, MS

– New cases per 100k in the past week: 175 (34 new cases, -8% change from previous week)
– Cumulative cases per 100k: 37,523 (7,273 total cases)
— 19.5% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 629 (122 total deaths)
— 43.9% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 39.6% (7,683 fully vaccinated)

Cohee // Wikimedia Commons

#2. Prentiss County, MS

– New cases per 100k in the past week: 183 (46 new cases, +283% change from previous week)
– Cumulative cases per 100k: 38,148 (9,585 total cases)
— 21.5% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 434 (109 total deaths)
— 0.7% less deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 43.8% (10,995 fully vaccinated)

NatalieMaynor // Wikimedia Commons

#1. Yalobusha County, MS

– New cases per 100k in the past week: 215 (26 new cases, +225% change from previous week)
– Cumulative cases per 100k: 38,578 (4,671 total cases)
— 22.9% more cases per 100k residents than Mississippi
– Cumulative deaths per 100k: 512 (62 total deaths)
— 17.2% more deaths per 100k residents than Mississippi
– Population that is fully vaccinated: 66.9% (8,104 fully vaccinated)